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(S,R,S)-AHPC-PEG6-C4-Cl

CAT:
804-HY-103606-01
Size:
50 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
(S,R,S)-AHPC-PEG6-C4-Cl - image 1

(S,R,S)-AHPC-PEG6-C4-Cl

  • CAS Number: 1835705-59-3
  • UNSPSC Description: (S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
  • Target Antigen: E3 Ligase Ligand-Linker Conjugates
  • Type: Reference compound
  • Related Pathways: PROTAC
  • Applications: Cancer-programmed cell death
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_9.html
  • Purity: 96.24
  • Solubility: DMSO : ≥ 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic)
  • Smiles: O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
  • Molecular Weight: 827.47
  • References & Citations: [1]Tovell H, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019 May 17;14(5):882-892.
  • Shipping Conditions: Room Temperature
  • Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
  • Clinical Information: No Development Reported