Sodium Channel inhibitor 1
CAT:
804-HY-15736-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Sodium Channel inhibitor 1
- CAS Number: 1198117-23-5
- UNSPSC Description: Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. IC50 Value: 0.16 uM ( Na v1.7, V hold-90mV); 0.41 uM (Na v1.7, V hold-90mV) [1] Target: Na v1.7 Sodium Channel inhibitor1 demonstrated concentration-dependent efficacy in preclinical behavioral pain models.
- Target Antigen: Sodium Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/sodium-channel-inhibitor-1.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(C1N(CCC2=NC=CC=C2)C(C3=C1C(F)=CC=C3)=O)NCC4=CC=C(OC(F)(F)F)C=C4
- Molecular Weight: 473.42
- References & Citations: [1]Macsari I, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported