Tubastatin A
CAT:
804-HY-13271A-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Tubastatin A
- CAS Number: 1252003-15-8
- UNSPSC Description: Tubastatin A is a potent and selective?HDAC6?inhibitor with?an IC50?of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein?2 (MBLAC2).
- Target Antigen: Apoptosis; Autophagy; Beta-lactamase; HDAC
- Type: Reference compound
- Related Pathways: Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage;Epigenetics
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/Tubastatin-A.html
- Purity: 98.37
- Solubility: DMSO : 12.5 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
- Smiles: O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1
- Molecular Weight: 335.40
- References & Citations: [1]Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846|[2]de Zoeten EF, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78.|[3]Di Fulvio S, et al. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One. 2011;6(12):e28563|[4]Ketene AN, et al. Actin filaments play a primary role for structural integrity and viscoelastic response in cells. Integr Biol (Camb). 2012 May;4(5):540-9.|[5]Kozyreva VK, et al. NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res. 2014 May;12(5):681-93.|[6]Brijmohan, Angela, et al. Role of HDAC6 in Transcription Factor EB Mediated Clearance of Misfolded Proteins in Chronic Kidney Disease. University of Toronto.Nov-2017.|[7]Lechner S, Malgapo MIP, Grätz C, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target [published online ahead of print, 2022 Apr 28]. Nat Chem Biol. 2022;10.1038/s41589-022-01015-5. |[8]Géraldy M, Morgen M, Sehr P, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019;62(9):4426-4443.|[9]Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.Acta Pharm Sin B. 20 May 2022.|Aging. 2021 Mar 19;13(7):9820-9837.|Am J Pathol. 2020 Dec;190(12):2376-2386.|Antioxidants (Basel). 2022 Apr 7;11(4):732.|Antioxidants. 2020 Jul 9;9(7):599.|Biochim Biophys Acta Mol Cell Res. 2020 May;1867(5):118676.|bioRxiv. 2021 Feb 25.|BMC Biol. 2018 Oct 18;16(1):116.|J Dermatol Sci. 2022 May 17;S0923-1811(22)00125-6.|J Med Chem. 2023 Nov 16.|J Med Chem. 2024 Aug 15.|J Mol Neurosci. 2024 Mar 13.|J Nutr. 2020 Jul 1;150(7):1790-1798.|Medical Science, University of Toronto. 2017 Nov.|Mol Cancer Res. 2014 May;12(5):681-93.|Mol Cancer Res. 2022 Mar 4;molcanres.0923.2021.|Neurotherapeutics. 2023 Jun 2.|NPJ Precis Oncol. 2024 Mar 7;8(1):66.|Patent. US20180263995A1.|Atherosclerosis. 2021 Jan;317:1-9.|Cell Death Dis. 2022 Oct 21;13(10):888.|Front Pharmacol. 2018 Feb 1;9:34.|Hum Mol Genet. 2022 Jan 12;ddac008.|Neurotherapeutics. 2023 Jun 2.|PLoS Pathog. 2021 Sep 20;17(9):e1009940.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported