Mirogabalin

Mirogabalin

• Product Name Alternative: DS5565
• CAS Number: 1138245-13-2
• UNSPSC Description: Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
• Target Antigen: Calcium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Mirogabalin.html
• Purity: 99.31
• Solubility: DMSO : < 1 mg/mL|H2O : 7.71 mg/mL (ultrasonic)
• Smiles: O=C(O)C[C@]1(CN)[C@]2([H])C=C(CC)C[C@]2([H])C1
• Molecular Weight: 209.289
• References & Citations: [1]Vinik A, et al. Efficacy and safety of Mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec|[2]Hutmacher MM, et al. Exposure-response modeling of average daily pain score, and dizziness and somnolence, forMirogabalin (DS-5565) in patients with diabetic peripheral neuropathic pain. J Clin Pharmacol. 2016 Jan;56(1):67-77.Brain Behav Immun. 2021 Jul;95:344-361.|Molecules. 2023 Nov 30, 28(23), 7862.|Pharmaceuticals. 2022, 15(1), 88.|Pharmaceuticals. 2023 Jul 19, 16(7), 1023.|Cell Commun Signal. 2024 Feb 1;22(1):92.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched