2-Hydroxycinnamic acid
CAT:
804-HY-W012531-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
2-Hydroxycinnamic acid
- CAS Number: 614-60-8
- UNSPSC Description: 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity[1][2][3][4].
- Target Antigen: Bacterial; Endogenous Metabolite; HIV; SARS-CoV
- Type: Natural Products
- Related Pathways: Anti-infection;Metabolic Enzyme/Protease
- Applications: COVID-19-anti-virus
- Field of Research: Cancer; Infection; Inflammation/Immunology; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/2-hydroxycinnamic-acid.html
- Purity: 98.30
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(O)/C=C/C1=CC=CC=C1O
- Molecular Weight: 164.16
- References & Citations: [1]Tran Minh Ngoc, et al. A new coumarin and cytotoxic activities of constituents from Cinnamomum cassia. Nat Prod Commun. 2014 Apr;9(4):487-8.|[2]Min Zhuang, et al. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Res. 2009 Apr;82(1):73-81.|[3]Keman D, et al. Antibiotic-Resistant Staphylococcus aureus Does Not Develop Resistance to Vanillic Acid and 2-Hydroxycinnamic Acid after Continuous Exposure in Vitro. ACS Omega. 2019 Sep 10;4(13):15393-15400.|[4]Hao S, et al. Hydroxycinnamic Acid from Corncob and Its Structural Analogues Inhibit Aβ40 Fibrillation and Attenuate Aβ40-Induced Cytotoxicity. J Agric Food Chem. 2020 Aug 19;68(33):8788-8796.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported