Tri-GalNAc(OAc)3-Perfluorophenyl

Tri-GalNAc(OAc)3-Perfluorophenyl

• UNSPSC Description: Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc(OAc)3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation. tri-GalNAc: triantenerrary N-acetylgalactosamine; LYTAC: lysosome-targeting chimera[1].
• Target Antigen: LYTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tri-galnac-oac-3-perfluorophenyl.html
• Solubility: 10 mM in DMSO|DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C(CCOCCOCCOCCOCCOCCC(OC1=C(F)C(F)=C(F)C(F)=C1F)=O)NC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]2COC(C)=O)[C@@H]([C@H]([C@H]2OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]3COC(C)=O)[C@@H]([C@H]([C@H]3OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]4COC(C)=O)[C@@H]([C@H]([C@H]4OC(C)=O)OC(C)=O)NC(C)=O)=O)=O
• Molecular Weight: 2280.29
• References & Citations: [1]Zhou Y, et al. Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins. ACS Cent Sci. 2021 Mar 24;7(3):499-506.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported