CD13 Antibody / ANPEP

CD13 Antibody / ANPEP

• Description: Recognizes an integral membrane glycoprotein of 150kDa, identified as CD13 (also known as aminopeptidase-N). The antibody recognizes an extracellular epitope. The CD13 antigen is present on most cells of myeloid origin including granulocytes, monocytes, mast cells, and GM-progenitor cells. It is also expressed by the majority of AML, CML in myeloid blast crisis, and in a smaller fraction of lymphoid leukemias. CD13 is absent from normal lymphocytes, platelets and erythrocytes. CD13 is also present on fibroblasts; endothelial cells, epithelial cells from renal proximal tubules and intestinal brush border, bone marrow stromal cells, osteoclasts, and cells lining bile duct canaliculi. CD13 is identical to aminopeptidase N (APN), a prominent membrane-bound metalloprotease present on the surface of intestinal brush border and renal tubules. CD13 plays a role in metabolism of biologically active peptides, in phagocytosis, and in bactericidal / tumoricidal activities. It also serves as a receptor for human coronaviruses (HCV). The lineage-restricted pattern of expression of CD13 within the hemopoietic compartment suggests that it may be important in myeloid cell differentiation.
• CAS Number: 9007-83-4
• UniProt: P15144
• Host: Mouse
• Immunogen: A portion of amino acids 50-250 from the human protein was used as the immunogen for the Aminopeptidase-N antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: ELISA, WB, IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Aliquot the Aminopeptidase-N antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This Aminopeptidase-N antibody is available for research use only.