TS-24

TS-24

• CAS Number: 1563260-97-8
• UNSPSC Description: TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis[1].
• Target Antigen: Apoptosis; Cathepsin
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ts-24.html
• Solubility: DMSO : ≥ 16.67 mg/mL
• Smiles: O=C(/C=C/C1=CN(C)C2=C1C=CC=C2)C3=CC4=CC=CC=C4O3
• Molecular Weight: 301.34
• References & Citations: [1]Choi E, et al., Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells. Cancer Sci. 2024 Apr 13.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported