LSP1 Antibody / Lymphocyte Specific Protein 1

LSP1 Antibody / Lymphocyte Specific Protein 1

• Description: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.
• CAS Number: 9007-83-4
• UniProt: P33241
• Host: Mouse
• Immunogen: A recombinant human partial protein (amino acids 174-278) was used as the immunogen for this LSP1 antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Store the LSP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This LSP1 antibody is available for research use only.