HER2 Antibody / ErbB2

HER2 Antibody / ErbB2

• Description: Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This mAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
• CAS Number: 9007-83-4
• UniProt: P04626
• Host: Mouse
• Immunogen: A portion of amino acids 311-462 from the human protein was used as the immunogen for this HER2 antibody.
• Clonality: Monoclonal
• Isotype: IgG2a κ
• Applications: IHC-P
• Format: Purified
• Buffer: Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
• Reconstitution: Store the HER2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This HER2 antibody is available for research use only.