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CD8A Antibody

CAT:
800-V2043-100UG
Size:
100 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
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CD8A Antibody

  • Description: CD8 is a cell surface receptor expressed either as a heterodimer with the beta chain or as a homodimer. A majority of thymocytes and a subpopulation of mature Tcells and NK cells express CD8a. It binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in Tcell development and activation of mature Tcells. For mature Tcells, CD8 and 4 are mutually exclusive, so antibody to CD8 is generally used in conjunction with antibody to CD4. CD8a antibody is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral Tcell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+/CD8-, and in T-lymphoblastic lymphoma/leukemia, they are often co-expressed. It is also found in littoral cell angioma of the spleen.
  • CAS Number: 9007-83-4
  • UniProt: P01732
  • Host: Mouse
  • Immunogen: Human recombinant protein was used as the immunogen for this CD8a antibody.
  • Clonality: Monoclonal
  • Isotype: IgG1 κ
  • Applications: IHC-P, IF
  • Format: Purified
  • Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
  • Reconstitution: Store the CD8a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • Limitations: This CD8a antibody is available for research use only.