CD8A Antibody
CAT:
800-V8824SAF-100UG
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CD8A Antibody
- Description: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
- CAS Number: 9007-83-4
- UniProt: P01732
- Host: Rabbit
- Immunogen: A recombinant fragment from the C-terminal cytoplasmic domain of the alpha chain of human CD8 was used as the immunogen for the CD8A antibody.
- Clonality: Polyclonal
- Isotype: IgG
- Applications: IHC-P
- Format: Purified
- Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
- Reconstitution: Aliquot the CD8A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
- Limitations: This CD8A antibody is available for research use only.