Grancalcin Antibody / GCA

Grancalcin Antibody / GCA

• Description: Grancalcin is a protein that in humans is encoded by the GCA gene. This gene is mapped to 2q24.2. This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
• CAS Number: 9007-83-4
• UniProt: P28676
• Host: Rabbit
• Immunogen: Amino acids A42-I217 from the human protein were used as the immunogen for the Grancalcin antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, IHC-P, IF, FACS, Direct ELISA
• Format: Purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the Grancalcin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.