LSD1 Antibody
CAT:
800-F41978-0.4ML
Size:
0.4 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
LSD1 Antibody
- Description: LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.
- CAS Number: 9007-83-4
- UniProt: O60341
- Host: Rabbit
- Immunogen: A portion of amino acids 108-142 from the human protein was used as the immunogen for this LSD1 antibody.
- Clonality: Polyclonal
- Isotype: Ig
- Applications: WB, IHC, IF, ELISA
- Format: Purified
- Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
- Reconstitution: Aliquot the LSD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
- Limitations: This LSD1 antibody is available for research use only.