FLT3/CHK1-IN-2
CAT:
804-HY-162367
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FLT3/CHK1-IN-2
- UNSPSC Description: FLT3/CHK1-IN-2 (Compound 30) is a dual inhibitor of FLT3 and CHK1, with IC50s of 25.63, 16.39, 22.80 nM for CHK1, FLT3-WT, and FLT-D835Y respectively. FLT3/CHK1-IN-2 has favorable oral PK properties and kinase selectivity. FLT3/CHK1-IN-2 can be used for research of acute myeloid leukemia (AML)[1].
- Target Antigen: Checkpoint Kinase (Chk); FLT3
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/flt3-chk1-in-2.html
- Solubility: 10 mM in DMSO
- Smiles: NCCCNC1=NC(NC2=CC(CCN(S(=O)(C)=O)C3)=C3C=C2)=NC=C1C(F)(F)F
- Molecular Weight: 444.47
- References & Citations: [1]Deng M, et al. Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1. RSC Med Chem. 2023 Dec 7;15(2):539-552.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported