Levocabastine (hydrochloride) (Standard)

Levocabastine (hydrochloride) (Standard)

• CAS Number: 79547-78-7
• UNSPSC Description: Levocabastine (hydrochloride) (Standard) is the analytical standard of Levocabastine (hydrochloride). This product is intended for research and analytical applications. Levocabastine (R 50547) hydrochloride is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine hydrochloride can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC)[1][2][3].
• Target Antigen: Histamine Receptor; Integrin; Neurotensin Receptor
• Type: Reference Standards
• Related Pathways: Cytoskeleton;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/levocabastine-hydrochloride-standard.html
• Smiles: OC([C@@]1(C2=CC=CC=C2)[C@@H](CN([C@]3([H])CC[C@](CC3)(C4=CC=C(C=C4)F)C#N)CC1)C)=O.[H]Cl
• Molecular Weight: 456.98
• References & Citations: [1]Folkerts G, et, al. Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells. Br J Pharmacol. 1993 Apr;108(4):1083-93.|[2]Yamauchi R, et, al. Effect of beta-lactotensin on acute stress and fear memory. Peptides. 2006 Dec;27(12):3176-82.|[3]Qasem AR, et, al. Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine. Biochem Pharmacol. 2008 Sep 15;76(6):751-62.
• Shipping Conditions: Room temperature