Taraxasterol

Taraxasterol

• CAS Number: 1059-14-9
• UNSPSC Description: Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases[1][2][3].
• Target Antigen: Interleukin Related; LXR
• Type: Natural Products
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/taraxasterol.html
• Purity: 99.41
• Solubility: DMSO : 1 mg/mL (ultrasonic;heat to 80°C)|Ethanol : 4 mg/mL (ultrasonic)
• Smiles: CC(C)([C@]1([H])CC[C@@]([C@](CC[C@@](CC2)3C)4C)5C)[C@@H](O)CC[C@]1(C)[C@@]5([H])CC[C@]4([H])[C@@]3([H])[C@H](C)C2=C
• Molecular Weight: 426.72
• References & Citations: [1]Zhang X, et al. Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol. 2012 May 7;141(1):206-11.|[2]Sang R, Yu Y, Ge B, Xu L, Wang Z, Zhang X. Taraxasterol from Taraxacum prevents concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways. Artif Cells Nanomed Biotechnol. 2019;47(1):3929-3937. |[3]Zheng F, et al. Anti-inflammatory effects of taraxasterol on LPS-stimulated human umbilical vein endothelial cells[J]. Inflammation, 2018, 41: 1755-1761.|[4]San Z, et al. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice[J]. International Immunopharmacology, 2014, 19(2): 342-350.|[5]Piao T, et al.Taraxasterol inhibits IL-1β-induced inflammatory response in human osteoarthritic chondrocytes. Eur J Pharmacol. 2015 Jun 5;756:38-42.|[6]Movahhed M, et al. Anti-metastatic effect of taraxasterol on prostate cancer cell lines. Res Pharm Sci. 2023 Jun 1;18(4):439-448.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported