FPFT-2216
CAT:
804-HY-145319-05
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FPFT-2216
- CAS Number: 2367619-87-0
- UNSPSC Description: FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease[1][2].
- Target Antigen: Casein Kinase; Molecular Glues; Phosphodiesterase (PDE)
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;PROTAC;Stem Cell/Wnt
- Applications: COVID-19-anti-virus
- Field of Research: Cancer; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/fpft-2216.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(C(N1N=NC(C2=CSC=C2OC)=C1)CC3)NC3=O
- Molecular Weight: 292.32
- References & Citations: [1]Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.|[2]Gemechu Y, et al. Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs. Proc Natl Acad Sci U S A. 2018;115(46):11802-11807.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported