18β-Glycyrrhetyl-3-O-sulfate

18β-Glycyrrhetyl-3-O-sulfate

• CAS Number: 10251-38-4
• UNSPSC Description: 18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research[1][2].
• Target Antigen: 11β-HSD; Drug Metabolite; OAT
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/18β-glycyrrhetyl-3-o-sulfate.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C)(C4)C(O)=O)C)=CC([C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)OS(=O)(O)=O)C)([H])CC2)C)=O)C
• Molecular Weight: 550.75
• References & Citations: [1]Kan'ichiro Ishiuchi, et al. 18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism. Sci Rep. 2019 Feb 7;9(1):1587.|[2]Kan'ichiro Ishiuchi, et al. Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported