α-Amyrin

α-Amyrin

• CAS Number: 638-95-9
• UNSPSC Description: α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission[1][2][3].
• Target Antigen: ERK; GSK-3
• Type: Natural Products
• Related Pathways: MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Metabolic Disease; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/α-amyrin.html
• Purity: 99.94
• Solubility: 10 mM in DMSO|Methanol : 1 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@H]([C@@H]4C)C)C)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC2)C)C
• Molecular Weight: 426.72
• References & Citations: [1]Giacoman-Martínez A, et al. α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. Can J Physiol Pharmacol. 2021 Sep;99(9):935-942.|[2]Prabhakar P, et al. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. Appl Physiol Nutr Metab. 2017 Jan;42(1):23-32.|[3]Park SJ, et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol Pharm Bull. 2014;37(7):1207-13.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported