1-Methyl-2-undecyl-4(1H)-quinolone

1-Methyl-2-undecyl-4(1H)-quinolone

• CAS Number: 59443-02-6
• UNSPSC Description: 1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC50 and Ki values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS[1][2].
• Target Antigen: Monoamine Oxidase
• Type: Natural Products
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/1-methyl-2-undecyl-4-1h-quinolone.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C=C(CCCCCCCCCCC)N(C)C2=C1C=CC=C2
• Molecular Weight: 313.48
• References & Citations: [1]Toshiya K, et al. Isolation and Structure Elucidation of Three Quinolone|[2]Lee MK, et al. 1-methyl-2-undecyl-4(1H)-quinolone as an irreversible and selective inhibitor of type B monoamine oxidase. Chem Pharm Bull (Tokyo). 2003;51(4):409-411.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported