Loperamide (hydrochloride)
CAT:
804-HY-B0418A-03
Size:
500 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Loperamide (hydrochloride)
- CAS Number: 34552-83-5
- UNSPSC Description: Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist[1][2][3]. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect[4].
- Target Antigen: Autophagy; Opioid Receptor
- Type: Reference compound
- Related Pathways: Autophagy;GPCR/G Protein;Neuronal Signaling
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Metabolic Disease; Neurological Disease; Cancer
- Assay Protocol: https://www.medchemexpress.com/Loperamide-hydrochloride.html
- Purity: 99.90
- Solubility: DMSO : 43.75 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 1 mg/mL (ultrasonic)
- Smiles: O=C(N(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(O)(C4=CC=C(Cl)C=C4)CC3.Cl
- Molecular Weight: 513.49846
- References & Citations: [1]Hanauer, S.B., The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord, 2008. 8(1): p. 15-20.|[2]Litovitz, T., et al., Surveillance of loperamide ingestions: an analysis of 216 poison center reports. J Toxicol Clin Toxicol, 1997. 35(1): p. 11-9.|[3]http://www.drugs.com/mmx/loperamide-hydrochloride.html|[4]Hatfield MJ, et al. Carboxylesterase inhibitors. Expert Opin Ther Pat. 2011 Aug;21(8):1159-71.|[5]Svenja Zielke, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2021, 17, 9.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched