RIPA-56

CAT:

26-B3051-5

Size:

5 mg

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Description: RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced necroptosis with an EC₅₀ of 28 nM. RIPA-56 efficiently reduces TNFα-induced mortality and multiorgan damage in a systemic inflammatory response syndrome (SIRS) mice model. Modulators of RIP kinase 1 may be beneficial against SARS-CoV-2 based on interaction of RIP kinase 1 with SARS-CoV-2 protein Nsp12.
Shipping Conditions: RT
Storage Conditions: -20ºC
Shelf Life: 36 months

Cat	Name
B3051-5	RIPA-56
B3051-25	RIPA-56
2114-100	RIPA Buffer
2114-500	RIPA Buffer
2592-25	AT 56
2592-5	AT 56
B2858-1000	YW3-56 (hydrochloride)
B2858-500	YW3-56 (hydrochloride)
P1514-10	Recombinant Coronavirus Spike Protein (MERS-CoV S1; 56-295)
P1514-50	Recombinant Coronavirus Spike Protein (MERS-CoV S1; 56-295)