DL-threo-Dihydrosphingosine

DL-threo-Dihydrosphingosine

• CAS Number: 2304-75-8
• UNSPSC Description: DL-threo-Dihydrosphingosine is a extracellular signal-regulated kinase(ERK) signalling cassette inhibitor and is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo-Dihydrosphingosine inhibits smooth muscle cell proliferation and can be used for study of asthma[1][2].
• Target Antigen: ERK
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;Stem Cell/Wnt
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/dl-threo-dihydrosphingosine.html
• Smiles: CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO
• Molecular Weight: 301.51
• References & Citations: [1]Tolan D, et al. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. Br J Pharmacol. 1996;119(2):185-186.|[2]Yoshida K, et al. ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice. J Allergy Clin Immunol. 2023;151(4):1067-1080.e9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported