GNE-0439
CAT:
804-HY-123824-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GNE-0439
- CAS Number: 1241902-40-8
- UNSPSC Description: GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].
- Target Antigen: Sodium Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/gne-0439.html
- Purity: 99.80
- Solubility: DMSO : 130 mg/mL (ultrasonic)
- Smiles: CC(C)[C@@H](C(O)=O)NC(C1=CC=C(C2CCC(CCC)CC2)C=C1)=O
- Molecular Weight: 345.48
- References & Citations: [1]Chernov-Rogan T, et al. Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported