Quercetin

Quercetin

• CAS Number: 117-39-5
• UNSPSC Description: Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].
• Target Antigen: Apoptosis; Autophagy; Mitophagy; PI3K; Reactive Oxygen Species
• Type: Natural Products
• Related Pathways: Apoptosis;Autophagy;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Quercetin.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)|Ethanol : 16.67 mg/mL (ultrasonic)
• Smiles: OC1=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1=O
• Molecular Weight: 302.24
• References & Citations: [1]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80.|[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.|[3]Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277.|[4]Tao Liu, et al. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Life Sci. 2020 Jul 20;118116.Adv Funct Mater. 27 January 2022.|Aging (Albany NY). 2021 Nov 25;13(22):24753-24767.|Aging. 2020 Jun 25;12(12):11337-11348.|Antioxidants (Basel). 2022 Feb 14;11(2):385.|Antioxidants (Basel). 2022 Nov 11;11(11):2222.|Antioxidants (Basel). 2024 Jul 29;13(8):918.|Behav Brain Res. 2022 Dec 16;114260.|Biogerontology. 2022 Apr 25:1-15.|Biology (Basel). 2024 Aug 29.|Biomed Pharmacother. 2024 Apr 25:175:116606.|Biomed Res Int. 23 Jul 2022.|Bioresour Bioprocess. 2024 Nov 27;11(1):108.|bioRxiv. 2023 Dec 20.|bioRxiv. 2024 Jul 30:2024.07.29.605645.|BMC Complement Med Ther. 2023 Dec 1;23(1):433.|BMC Complement Med Ther. 2023 Mar 23;23(1):89.|Cell Mol Gastroenterol Hepatol. 2022 Apr 2;14(1):75-99.|Chem Biol Drug Des. 2024 Apr;103(4):e14520.|Chem Biol Interact. 2024 May 19:396:111064.|Chin J Integr Med. 2022 Nov 14;1-8.|Chin Med. 2024 Mar 18;19(1):48.|Comput Struct Biotechnol J. 1 October 2021.|Ecotoxicol Environ Saf. 2024 Sep 30:285:117136.|Environ Pollut. 25 August 2021, 118036.|Eur J Med Chem. 2018 Mar 25;148:63-72. |Eur J Med Res. 2022 Dec 15;27(1):292.|Evid Based Complement Alternat Med. 2022 May 9;2022:2256671.|Evid-Based Compl Alt. 26 Aug 2021.|Exp Cell Res. 2020 Aug 1;393(1):112054.|Exp Eye Res. 2022 Aug 2;223:109207.|Exp Eye Res. 2023 Feb 15;109416.|Exp Ther Med. 2021 Mar 8.|Food Chem Toxicol. 2024 Jul 23:114877.|Food Chem. 2022: 134807.|Free Radic Biol Med. 2024 Jan 6:S0891-5849(24)00002-9.|Front Cardiovasc Med. 2022; 9: 804801.|Front Oncol. 2022 Aug 10;12:882784.|Genomics. 2021 Jun 7;S0888-7543(21)00220-2.|Heliyon. 2024 Jul 31.|Heliyon. 2024 Sep 20;10(19):e38122.|Immunobiology. 2022 Dec 30;228(2):152324.|Immunobiology. 2022: 152324.|Inflamm Res. 2020 Dec;69(12):1201-1213.|Insects. 2018 Jun 29;9(3). pii: E77. |Int Immunopharmacol. 2024 Sep 27;142(Pt B):113162.|Int J Insect Sci. 2018 Feb 28;10:1179543318758409.|Int J Mol Med. 2023 Dec;52(6):116.|Int J Mol Med. 2025 Jan;55(1):4.|Int J Mol Sci. 2024 Apr 4;25(7):4031.|Int J Mol Sci. 2024 Jul 7;25(13):7461.|International Journal of Human Anatomy. 2020 Dec.|J Agric Food Chem. 2020 Jul 29;68(30):8050-8056.|J Agric Food Chem. 2023 May 3.|J Agric Food Chem. 2024 Mar 27;72(12):6651-6659.|J Anim Sci Biotechnol. 2024 Sep 5;15(1):119.|J Ethnopharmacol. 2024 Jul 11:118576.|J Food Biochem. 2024 Aug 28.|J Funct Foods. 2024 Aug.|J Inflamm Res. 2021 Dec 7;14:6601-6618.|J Mol Liq. 23 November 2021, 118164.|J Periodontal Res. 2023 Aug 3.|Journal of Traditional Chinese Medical Sciences. 2024 Jun 12.|Life Sci. 2020 Sep 15;257:118116.|Medicine. 2023 Oct 13;102(41):e35384.|Mol Med Rep. 2024 Feb;29(2):26.|Molecules. 2020 Apr 23;25(8):1980.|Molecules. 2023 Mar 23.|Nat Aging. 2024 Apr;4(4):527-545.|Naunyn Schmiedebergs Arch Pharmacol. 2023 May 6.|Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 2.|Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug 2.|Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun 18.|Osteoarthritis Cartilage. 2021 Mar;29(3):413-422.|Oxid Med Cell Longev. 05 Sept 2022.|Pharmacological Research-Modern Chinese Medicine. 2024 Mar, 10, 100360.|Plant Foods Hum Nutr. 2022 Aug 20.|Plant Methods. 2022 Jun 23;18(1):87.|PLoS One. 2024 Jul 11;19(7):e0305612.|Research Square Preprint. 2021. Jul.|Respir Res. 2024 Aug 2;25(1):294.|Sci Rep. 2024 Jun 20;14(1):14183.|Thorac Cancer. 2021 Mar 11.|Tissue Eng Regen Med. 2024 Jul 26.|Virus Res. 2021 Sep 4;198556.|World J Stem Cells. 2023 Aug 26; 15(8): 842-865.|Mol Carcinog. 2024 Aug 22.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched