Anti-Hu CD129 Purified

Anti-Hu CD129 Purified

• Background: CD129 serves as the high affinity alpha subunit of IL-9 receptor. It associates with CD132, the common gamma chain shared by receptors of many different cytokines. CD129 is expressed at low levels by T and B cells, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons. Its signaling (through JAK/STAT pathways) results in proliferative and anti-apoptotic response, which is critical e.g. for intrathymic T cell development and survival of various cell types. The gene for CD129 is located at the pseudoautosomal regions of X and Y chromosomes and it may be related with the development of asthma.
• Specifications: The mouse monoclonal antibody AH9R7 recognizes an extracellular epitope of CD129 / IL-9R alpha, a 57 kDa type I transmembrane glycoprotein expressed at low levels by lymphocytes, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Human CD129-transfected cell line
• Target Antigen: CD129
• Isotype: IgG2b κ
• Clone: AH9R7
• Applications: Flow cytometry: It is recommended to use bright fluorochromes or signal multiplying detection.
• Validated Applications: FC, ELISA
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *De Smedt M, Verhasselt B, Kerre T, Vanhecke D, Naessens E, Leclercq G, Renauld JC, Van Snick J, Plum J: Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development. J Immunol. 2000 Feb 15164(4):1761-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/10657622,*Grasso L, Huang M, Sullivan CD, Messler CJ, Kiser MB, Dragwa CR, Holroyd KJ, Renauld JC, Levitt RC, Nicolaides NC: Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a splice variant encoding for a nonfunctional cell surface receptor. J Biol Chem. 1998 Sep 11273(37):24016-24., URL: https://www.ncbi.nlm.nih.gov/pubmed/9727018,*Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta. J Immunol. 2002 Apr 15168(8):4103-11. , URL: http://www.ncbi.nlm.nih.gov/pubmed/11937570 De Sme,*Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9. Eur Respir J. 2002 Nov20(5):1198-205., URL: http://www.ncbi.nlm.nih.gov/pubmed/12449174 Grasso,
• Storage Conditions: Store at 2-8°C. Do not freeze.