(S)-Amisulpride

(S)-Amisulpride

• Product Name Alternative: Esamisulpride; SEP-4199
• CAS Number: 71675-92-8
• UNSPSC Description: (S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects[1][2].
• Target Antigen: 5-HT Receptor; Dopamine Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/s-amisulpride.html
• Purity: 99.75
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC(S(=O)(CC)=O)=C(C=C1OC)N)NC[C@H]2N(CCC2)CC
• Molecular Weight: 369.48
• References & Citations: [1]Timothy J Donahue, et al. (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics. Eur J Pharmacol. 2014 Jul 5;734:15-22.|[2]Vincent Grattan, et al. Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D₂ and D₃, while R Enantiomers Engage 5-HT₇. ACS Omega. 2019 Aug 15;4(9):14151-14154.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 3