Anti-CD86 [OX-48], Mouse IgG1, kappa

Anti-CD86 [OX-48], Mouse IgG1, kappa

• Gene Name: [CD86]
• NCBI Gene ID: 56822
• Reactivity: Rat
• Storage Conditions: Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.
• Specificity: OX-48 binds specifically to CD86 targets which are present on subsets of T and B blasts, spleen macrophages and polymorphs, peritoneal macrophages, dendritic cells. OX48 does not appear to bind the same epitope of CD86 as 24F (Stephens et al. 2004). CD86 is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes - expression is rapidly upregulated by B cell specific stimuli. CD86 acts as a ligand for CD28 and CTLA-4. CD86 works in tandem with CD80 to prime T cells. 2 splice isoforms exist.
• Other Gene Names: [Cd86; Cd86; B7-2]
• Short Name: [CD86]
• Other Product Names: [B7-2; B7-2; T-lymphocyte activation antigen CD86; cd86 antigen; membrane glycoprotein; CD86 molecule; B7-2]
• NCBI GI Number: 81863176
• NCBI Accession Number: Q62810
• Uniprot Accession Number: Q62810