Polyphyllin G

• CAS Number: 76296-75-8
• UNSPSC Description: Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs)[1]. Polyphyllin G induces apoptosis dependent on the activations of caspase-8, -3, and -9, induces autophagy[2].
• Target Antigen: Apoptosis; Autophagy; Bacterial
• Type: Natural Products
• Related Pathways: Anti-infection;Apoptosis;Autophagy
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/polyphyllin-g.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@H]1[C@H]2[C@@H](O[C@@]1(OC)CC[C@H](CO[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C)C[C@@H]4[C@]2(C)CC[C@H]5[C@H]4CC=C6[C@]5(C)CC[C@H](O[C@@H]7[C@@H](O)[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O[C@H]9[C@H](O)[C@@H](O)[C@H](CO)O9)[C@H](CO)O7)C6
• Molecular Weight: 1049.20
• References & Citations: [1]Cai X, et al. Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2. Arch Biochem Biophys. 2018 Apr 15;644:93-99.|[2]Hsieh MJ, et al. Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells. Phytomedicine. 2016 Dec 1;23(13):1545-1554.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported