Rutin

Rutin

• CAS Number: 153-18-4
• UNSPSC Description: Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress[1][2][3][4][5].
• Target Antigen: Amyloid-β; Apoptosis; Autophagy; Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: COVID-19-anti-virus
• Field of Research: Inflammation/Immunology; Cancer
• Assay Protocol: https://www.medchemexpress.com/Rutin.html
• Purity: 98.09
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(O)=CC(O)=C15
• Molecular Weight: 610.52
• References & Citations: [1]Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312.|[2]Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.|[3]Xu PX, et al. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180.|[4]Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377.|[5]Carlquist M, et al. Flavonoids as inhibitors of human carbonyl reductase 1. Chem Biol Interact. 2008 Jul 30;174(2):98-108. Antioxidants (Basel). 2023 Nov 7, 12(11), 1974.|Biology (Basel). 2024 Aug 29.|Food Chem. 16 December 2021, 131872.|Food Chem. 2022: 134807.|Food Res Int. 2024 Oct:193:114812.|iScience. 2023 Sep 6.|Pharmacogn Mag. 2023 Oct 12.|Phytomedicine. 2023 Feb 4;112:154700.|ACS Omega. 2024 Feb 28;9(10):11870-11882.|Adv Sci (Weinh). 2022 Oct 18;e2203088.|Neurotoxicology. 2024 Jul 18:S0161-813X(24)00082-2.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched