L-Kynurenine
CAT:
804-HY-104026-03
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
L-Kynurenine
- CAS Number: 2922-83-0
- UNSPSC Description: L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
- Target Antigen: Aryl Hydrocarbon Receptor; Endogenous Metabolite
- Type: Natural Products
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/L-Kynurenine.html
- Purity: 99.93
- Solubility: DMSO : 11.67 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 20 mg/mL (ultrasonic)
- Smiles: O=C(O)[C@@H](N)CC(C1=CC=CC=C1N)=O
- Molecular Weight: 208.217
- References & Citations: [1]Moyer BJ, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.|[2]Sakakibara K, et al. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7.|[3]Nozaki K, et al. Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab. 1992 May;12(3):400-7.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: Phase 1