(R)-(-)-Ibuprofen-d3

(R)-(-)-Ibuprofen-d3

• CAS Number: 121702-86-1
• UNSPSC Description: (R)-(-)-Ibuprofen-d3 is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
• Target Antigen: Isotope-Labeled Compounds; NF-κB
• Type: Isotope-Labeled Compounds
• Related Pathways: NF-κB;Others
• Field of Research: Inflammation/Immunology; Cancer
• Purity: 99.97
• Solubility: 10 mM in DMSO
• Smiles: OC([C@@H](C1=CC=C(C=C1)CC(C)C)C([2H])([2H])[2H])=O
• Molecular Weight: 209.30
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[3]Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported