NT5E antibody

NT5E antibody

• Background: NT5E(5'-nucleotidase) is also named as NT5, NTE,CD73,ecto-5'-nucleotidase, and belongs to the 5'-nucleotidase family. It catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP.The enzyme occurs mainly as a dimer and the wide distribution of NT5E in the rat hippocampus, suggesting their involvement in the control of the purinergic signaling(PMID:17619139). This protein has two isoforms with the molecular weight of 63 kDa and 58 kDa and four glycosylation sites with a signalpeptide. It can exsit as a dimer(PMID:17619139). It can be detected the band of 55 kDa,64 kDa, 70 kDa, 110 kDa by western blot(PMID:17619139; 12370277; 21533188). Defects in NT5E are the cause of calcification of joints and arteries(CALJA).
• Synonyms: 5'-nucleotidase (5'-NT)|5'-deoxynucleotidase|Ecto-5'-nucleotidase|IMP-specific 5'-nucleotidase|Thymidylate 5'-phosphatase|NT5E|NT5|NTE
• CAS Number: 9007-83-4
• Gene ID: 4907
• UniProt: P21589
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: 5'-nucleotidase, ecto(CD73)
• Target: NT5E
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB,IHC,FC
• Field of Research: Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500-1:5000; IHC: 1:50-1:500
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 63 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)