MGME1 antibody

MGME1 antibody

• Background: Metal-dependent single-stranded DNA(ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA(mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine(5hmC)-containing DNA in stem cells.
• Synonyms: Mitochondrial genome maintenance exonuclease 1|MGME1|C20orf72|DDK1
• CAS Number: 9007-83-4
• Gene ID: 92667
• UniProt: Q9BQP7
• Host: Rabbit
• Reactivity: Human, Mouse
• Immunogen: chromosome 20 open reading frame 72
• Target: MGME1
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB, IHC
• Field of Research: Metabolism
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 36-39 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)