DKK1 antibody

DKK1 antibody

• Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
• Synonyms: Dickkopf-related protein 1 (Dickkopf-1, Dkk-1, hDkk-1)|SK|DKK1
• CAS Number: 9007-83-4
• Gene ID: 22943
• UniProt: O94907
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: dickkopf homolog 1
• Target: DKK1
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB, IF, IHC
• Field of Research: Signal Transduction, Developmental biology
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 30-35 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)