WS-898
CAT:
804-HY-139848-06
Size:
100 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
WS-898
- CAS Number: 2891562-77-7
- UNSPSC Description: WS-898 is a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC50 = 5.0, 3.67, and 3.68 nM, respectively).
- Target Antigen: P-glycoprotein
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/ws-898.html
- Solubility: DMSO : ≥ 25 mg/mL
- Smiles: O=C(/C=C/C1=CC=C(C=CC=C2)C2=C1)C3=CC=C(NC4=CC(C)=NC5=NC(SCC6=NC7=C(C=CC=C7)N6)=NN54)C=C3
- Molecular Weight: 567.66
- References & Citations: [1]Wang S, et al. Discovery of the Triazolo[1,5-a]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance. J Med Chem. 2021 Nov 11;64(21):16187-16204.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported