Spebrutinib (besylate)
CAT:
804-HY-18012A
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Spebrutinib (besylate)
- CAS Number: 1360053-81-1
- UNSPSC Description: Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50Kinact/Ki=7.69×104 M-1s-1s) in biochemical assays.
- Target Antigen: Btk
- Type: Reference compound
- Related Pathways: Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/AVL-292-benzenesulfonate.html
- Solubility: 10 mM in DMSO
- Smiles: COCCOC1=CC=C(NC2=NC=C(F)C(NC3=CC=CC(NC(C=C)=O)=C3)=N2)C=C1.O=S(C4=CC=CC=C4)(O)=O
- Molecular Weight: 581.62
- References & Citations: [1]Evans EK, et al. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 2