AZD1208 (hydrochloride)
CAT:
804-HY-15604A
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
AZD1208 (hydrochloride)
- CAS Number: 1621866-96-3
- UNSPSC Description: AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor[1].
- Target Antigen: Apoptosis; Autophagy; Pim
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;JAK/STAT Signaling
- Applications: Neuroscience-Neuromodulation
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/AZD1208_hydrochloride.html
- Solubility: DMSO : 83.3 mg/mL (ultrasonic;warming)
- Smiles: O=C(NC/1=O)SC1=C/C2=C(N3C[C@H](N)CCC3)C(C4=CC=CC=C4)=CC=C2.[H]Cl
- Molecular Weight: 415.94
- References & Citations: [1]Dakin LA, et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604.|[2]Kreuz S, et al. Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. Mol Cancer. 2015 Dec 8;14:205.|[3]Harada M, et al. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget. 2015 Nov 10;6(35):37930-47.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 1