Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein, Tag Free
CAT:
716-ALN-H5114-1mg
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: Yes
Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein, Tag Free
- Background: Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
- Description: Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein, Tag Free (ALN-H5114) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (A53T)).
- Specifications: This protein carries no "tag". The protein has a calculated MW of 14.5 kDa.
- Expression Region: Met 1 - Ala 140
- Host: E. coli
- Target: Alpha-Synuclein
- Conjugation: Unconjugated
- Tag: Native
- Source: Human
- Stability: The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C; The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions; The sonicated fibril should be stored at -70°C for not more than 8 weeks.
- Endotoxin: 1.0 EU per μg
- Purity: 90%
- Format: Liquid
- Buffer: PBS, pH7.4
- Additives: Trehalose
- Molecular Weight: 14.5 kDa
- Shipping Conditions: Dry ice
- Storage Conditions: -70°C