PARP1/c-Met-IN-1

PARP1/c-Met-IN-1

• CAS Number: 2944101-99-7
• UNSPSC Description: PARP1/c-Met-IN-1 (Compound 16) is a selective dual inhibitor for PARP1 and c-Met, with IC50s of 3.3 and 32.2 nM, respectively. PARP1/c-Met-IN-1 induces cell apoptosis and cell cycle arrest in G2/M phase in MDA-MB-231 cells. PARP1/c-Met-IN-1 exhibits antitumor activity in mice[1].
• Target Antigen: Apoptosis; c-Met/HGFR; PARP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp1-c-met-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C=CC(C2=CC=CN=C2)=NN1CCOC3=C4C(C=C(C=C4)N5CCN(CC5)C(C6=C(C=CC(CC7=NNC(C8=C7C=CC=C8)=O)=C6)F)=O)=NC=C3
• Molecular Weight: 708.74
• References & Citations: [1]Sun Z, et al., Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression. J Med Chem. 2024 Mar 28;67(6):4916-4935.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported