Mavacamten-d5

• CAS Number: 2453251-00-6
• UNSPSC Description: Mavacamten-d5 (MYK461-d5; SAR439152-d5) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
• Target Antigen: Isotope-Labeled Compounds; Myosin
• Type: Isotope-Labeled Compounds
• Related Pathways: Cytoskeleton;Others
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Purity: 98.61
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC(N1C(C=C(NC1=O)N[C@H](C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C)=O)C
• Molecular Weight: 278.36
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292(40):16571-16577.|[3]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11(12):e0168407.|[4]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported