Mavacamten

• CAS Number:

  1642288-47-8

• UNSPSC Description:

  Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

• Target Antigen:

  Myosin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Mavacamten.html

• Purity:

  99.94

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  CC(N(C1=O)C(C=C(N[C@H](C2=CC=CC=C2)C)N1)=O)C

• Molecular Weight:

  273.336

• References & Citations:

  [1]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292(40):16571-16577.|[2]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11(12):e0168407.|[3]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  Launched