Anti-Phospho-PKCth (Ser676) PRKCQ Antibody

Anti-Phospho-PKCth (Ser676) PRKCQ Antibody

• Background: This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.
  
  Kristof Van Kolen, et al. (2006) FEBS J ; 273: 1843 - 1854.
  Martin Villalba, et al. (2002) J. Cell Biol ; 157: 253.
  Jie Zhang, et al. (2004) J. Biol. Chem ; 279: 22118 - 22123.
  Castro AF, et al. (1998) Am J Physiol Cell Physiol; 275: C113 - C119.
• Description: Boster Bio Anti-Phospho-PKCth (Ser676) PRKCQ Antibody (Catalog # P01293). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
• Synonyms: Protein kinase C theta type;2.7.11.13;nPKC-theta;PRKCQ;PRKCT;
• CAS Number: 9007-83-4
• Gene Name: PRKCQ
• UniProt: Q04759
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: Peptide sequence around phosphorylation site of serine 676 (R-L-S(p)-F-A) derived from Human PKCth.
• Clonality: Polyclonal
• Applications: WB, IHC, IF
• Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
• Concentration: 1 mg/ml
• Form: Liquid
• Molecular Weight: 81865 MW
• Components: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.