Anti-SAMHD1 Monoclonal Antibody

Anti-SAMHD1 Monoclonal Antibody

• Description: Boster Bio Anti-SAMHD1 Monoclonal Antibody catalog # M00592. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.
• Synonyms: Transferrin receptor protein 1;TR;TfR;TfR1;Trfr;T9;p90;CD71;Transferrin receptor protein 1, serum form;sTfR;TFRC;
• CAS Number: 9007-83-4
• Gene Name: Transferrin receptor protein 1
• UniProt: Q9Y3Z3
• Host: Rabbit
• Reactivity: Human
• Immunogen: A synthesized peptide derived from human SAMHD1
• Clonality: Monoclonal
• Clone: Clone: AEEA-19
• Tissue Specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
• Applications: WB,IHC,ICC,IF,Flow Cytometry
• Purification: Affinity-chromatography
• Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Form: Liquid
• Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
• Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. .
• Components: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
• Storage Conditions: Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 84871 MW
• Observed Molecular Weight: 32-42 kDa, 65 kDa, 75 kDa
• Fragment: Rabbit IgG
• Applications Notes: WB 1:1000-1:5000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200
  FC 1:50
• Subcellular Location: Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
• Protein Name: T-cell surface glycoprotein CD4