Anti-Histone H2A.X H2AFX Rabbit Monoclonal Antibody
CAT:
519-M00241-1
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Histone H2A.X H2AFX Rabbit Monoclonal Antibody
- Description: Boster Bio Anti-Histone H2A.X H2AFX Rabbit Monoclonal Antibody catalog # M00241-1. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.
- Synonyms: Histone H2AX;H2a/x;Histone H2A.X;H2AFX;H2AX;
- CAS Number: 9007-83-4
- Gene Name: Histone H2AX
- UniProt: P16104
- Host: Rabbit
- Reactivity: Human,Mouse,Rat
- Immunogen: A synthesized peptide derived from human Histone H2A.X
- Clonality: Monoclonal
- Clone: Clone: BIA-8
- Tissue Specificity: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
- Applications: WB,IHC,ICC,IF,IP
- Purification: Affinity-chromatography
- Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
- Form: Liquid
- Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
- Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. .
- Components: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
- Storage Conditions: Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.
- Calculated Molecular Weight: 15145 MW
- Observed Molecular Weight: 100-110 kDa
- Fragment: Rabbit IgG
- Applications Notes: WB 1:500-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200
IP 1:50 - Subcellular Location: Nucleus . Chromosome .
- Protein Name: P2X purinoceptor 1