Anti-ErbB2 (HER2) Monoclonal Antibody

Anti-ErbB2 (HER2) Monoclonal Antibody

• Description: Boster Bio Anti-ErbB2 (HER2) Monoclonal Antibody catalog # M00010-1. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human.
• Synonyms: Signal transducer and activator of transcription 3;Acute-phase response factor;STAT3;APRF;
• CAS Number: 9007-83-4
• Gene Name: Signal transducer and activator of transcription 3
• UniProt: P04626
• Host: Rabbit
• Reactivity: Human
• Immunogen: A synthesized peptide derived from human ErbB2 (HER2).
• Clonality: Monoclonal
• Clone: Clone: BCI-5
• Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
• Applications: WB,IHC,ICC,IF,IP,Flow Cytometry
• Purification: Affinity-chromatography
• Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Form: Liquid
• Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
• Function: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). .
• Components: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
• Storage Conditions: Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 88068 MW
• Observed Molecular Weight: 54 kDa
• Fragment: Rabbit IgG
• Applications Notes: WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200
  IP 1:50
  FC 1:50
• Subcellular Location: Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
• Protein Name: P2X purinoceptor 1