Anti-ABCB1/Mdr1 Antibody
CAT:
519-A00049
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Anti-ABCB1/Mdr1 Antibody
- Background: This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.
- Description: Boster Bio Anti-ABCB1/Mdr1 Antibody (Catalog # A00049). Tested in ELISA, IHC, WB applications. This antibody reacts with Human.
- Synonyms: ABCB1, ABCB 1, ABCB-1, ATP binding cassette sub family B MDR/TAP member 1, CD243, CD243 antigen, CLCS, GP170, MDR 1
- CAS Number: 9007-83-4
- Gene Name: ABCB1
- UniProt: P08183
- Host: Rabbit
- Reactivity: Human
- Cross Reactivity: No cross reactivity with other proteins.
- Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 255-280 of human ABCB1 protein.
- Clonality: Polyclonal
- Applications: ELISA, IHC, WB
- Purification: This affinity-purified antibody is directed against human ABCB1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with ABCB1 protein from human, monkey, dog, mouse, and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
- Concentration: 1.0 mg/mL by UV absorbance at 280 nm
- Form: Liquid (sterile filtered)
- Molecular Weight: 141479 MW
- Components: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide
- Storage Conditions: Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
- Fragment: IgG
- Applications Notes: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry, and western blot.