QC-182

QC-182

• CAS Number: 3032646-96-8
• UNSPSC Description: QC-182 is a potent PROTAC degrader of p300/CBP. QC-182 reduces p300 protein in the SK-HEP-1 cells (DC50 = 93nM). QC-182 potently and effectively inhibits cell growth in the SK-HEP-1 and JHH7 cell lines with IC50 values of 0.733 and 0.477 μM, respectively. QC-182 can be used for the research of hepatocellular carcinoma (HCC)[1].
• Target Antigen: Histone Acetyltransferase; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/qc-182.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C2C(NC(CC2)=O)=O)C(C(C1=C3)=CC=C3N(C4)CC4N5CCC(N6C7=CC=C(C8=C(C)ON=C8C)C=C7N=C6[C@H]9N(C%10=CC(F)=C(F)C=C%10)C(CCC9)=O)CC5)=O
• Molecular Weight: 816.85
• References & Citations: [1]Chang Q, et al. Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma. J Med Chem. 2024 Feb 22;67(4):2466-2486.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported