Mexiletine (hydrochloride)
CAT:
804-HY-A0093-03
Size:
500 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Mexiletine (hydrochloride)
- CAS Number: 5370-01-4
- UNSPSC Description: Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research[1][2][3][4][5].
- Target Antigen: Sodium Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Applications: COVID-19-immunoregulation
- Field of Research: Neurological Disease; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/Mexiletine-hydrochloride.html
- Purity: 99.92
- Solubility: DMSO : ≥ 41 mg/mL|H2O : 100 mg/mL (ultrasonic)
- Smiles: CC(N)COC1=C(C)C=CC=C1C.[H]Cl
- Molecular Weight: 215.72
- References & Citations: [1]Campbell RW, et al. Mexiletine. N Engl J Med. 1987，316(1):29-34.|[2]De Bellis M, et al. Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels. Biophys J. 2013，104(2):344-54.|[3] Nasilli G, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010;112(4):473-6.|[4]Egashira N, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010，112(4):473-6.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched